Coronavirus Pandemic Replace 69: "NAC" Supplementation and COVID-19 (N-Acetylcysteine)

COVID-19 Update 69 with Roger Seheult, MD of https://www.medcram.com
N-Acetylcysteine (NAC) is an over the counter supplement that has been utilized by clinicians for years to treat acetaminophen (Tylenol) overdose, as a mucolytic, and for other medical problems. There is compelling research that NAC may also reduce the severity of viral infections like influenza, and perhaps reduce the risk of blood clots (thromboembolism) as well. Could NAC be effective in COVID-19? Dr. Seheult illustrates these ideas and discusses the peer-reviewed data involved.

Links referenced in this video:

Johns Hopkins Tracker – https://coronavirus.jhu.edu/map.html

https://www.worldometers.info/coronavirus/

Taylor & Francis – https://www.tandfonline.com/doi/pdf/10.1080/10715762.2018.1468564

European Respiratory Journal – https://www.ncbi.nlm.nih.gov/pubmed/9230243

Biochemical Pharmacology – https://www.ncbi.nlm.nih.gov/pubmed/19732754

Free Radical Research – https://www.ncbi.nlm.nih.gov/pubmed/29742938

Experimental and Therapeutic Medicine – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590037/

Medicine – https://journals.lww.com/md-journal/FullText/2018/11090/N_acetylcysteine_improves_oxidative_stress_and.35.aspx

Journal of Medical Toxicology – https://www.ncbi.nlm.nih.gov/pubmed/22733602

Blood Coagulation & Fibrinolysis – https://journals.lww.com/bloodcoagulation/Abstract/2006/01000/The_effect_of_N_acetylcysteine_on_blood.6.aspx

Redox Biology – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619994/

Circulation – https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.117.027290

Blood Advances – https://ashpublications.org/bloodadvances/article/4/2/312/431284/N-acetylcysteine-inhibits-thrombosis-in-a-murine

Journal of Clinical Investigation 1 – https://www.ncbi.nlm.nih.gov/pubmed/21266777

Journal of Clinical Investigation 2 – https://www.jci.org/articles/view/41062/figure/2

CEBM – https://www.cebm.net/covid-19/n-acetylcysteine-a-rapid-review-of-the-evidence-for-effectiveness-in-treating-covid-19/

Clinical Trials – https://clinicaltrials.gov/ct2/show/NCT04374461

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999661/

Some previous videos from this series (visit MedCram.com for the full series):
– Coronavirus Pandemic Update 68: Kawasaki Disease; Minority Groups & COVID-19: https://youtu.be/Ja-jhcXMGj0
– Coronavirus Pandemic Update 67: COVID-19 Blood Clots – Race, Blood Types, & Von Willebrand Factor https://youtu.be/JOlVkES_kC8
– Coronavirus Pandemic Update 66: ACE-Inhibitors and ARBs – Hypertension Medications with COVID-19 https://youtu.be/OudhmwulJHY
– Coronavirus Pandemic Update 65: COVID-19 and Oxidative Stress (Prevention & Risk Factors) https://youtu.be/gzx8LH4Fjic
– Coronavirus Pandemic Update 64: Remdesivir COVID-19 Treatment Update https://youtu.be/Z2hfGcTokiY
– Coronavirus Pandemic Update 63: Is COVID-19 a Disease of the Endothelium (Blood Vessels and Clots)? https://youtu.be/Aj2vB_VITXQ
– Coronavirus Pandemic Update 62: Treatment with Famotidine (Pepcid)? https://youtu.be/DtPwfihjyrY
– Coronavirus Pandemic Update 61: Blood Clots & Strokes in COVID-19; ACE-2 Receptor; Oxidative Stress https://youtu.be/22Bn8jsGI54
– Coronavirus Pandemic Update 60: Hydroxychloroquine Update; NYC Data; How Widespread is COVID-19? This video was removed by YouTube
– Coronavirus Pandemic Update 59: Dr. Seheult’s Daily Regimen (Vitamin D, C, Zinc, Quercetin, NAC) https://youtu.be/NM2A2xNLWR4
– Coronavirus Pandemic Update 58: Testing; Causes of Hypoxemia in COVID 19 (V/Q vs Shunt vs Diffusion) https://youtu.be/nO4xgcIaPeA
– Coronavirus Pandemic Update 57: Remdesivir Treatment Update and Can Far-UVC Disinfect Public Spaces? https://youtu.be/2U4DAQ3kjRs
– Coronavirus Pandemic Update 56: What is “Forest Bathing” & Can It Boost Immunity Against Viruses? https://youtu.be/PgDjVEpEOdQ
– Coronavirus Outbreak / Pandemic Update 55: How COVID 19 Infection Attacks The Immune System & Differs From HIV: https://youtu.be/8NffZAGELGg
– How Coronavirus Kills: Acute Respiratory Distress Syndrome (ARDS) & Treatment: https://youtu.be/okg7uq_HrhQ

All coronavirus updates are at MedCram.com, and we offer many other medical topics (ECG Interpretation, strokes, thrombosis, pulmonary embolism, myocardial infarction, hypercoagulation, hypertension, anticoagulation, DKA, acute kidney injury, influenza, measles, mechanical ventilation, etc.).

Speaker: Roger Seheult, MD
Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.

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